Plastic from Corn Waste

An Indian entrepreneur is using sugar, cellulose, and corn fibers to create a plastic-like bag for small Indian businesses. His company, Bio Reform, has already replaced 6 million plastic bags at checkout counters across India.

Based in Hyderabad, Mohammed Azhar Mohiuddin conceived the idea during the pandemic. He focused on society’s heavy reliance on plastic, particularly plastic shopping bags, and sought an alternative.

While large brands were switching to paper or jute alternatives, small and medium businesses in India found biodegradable bags too expensive. Mohiuddin researched a biodegradable polymer called PBAT (Polybutylene adipate-co-terephthalate), developed in the 1980s using corn and potatoes.

After navigating scams and government quarantines to find suitable machinery in Gujarat, his presentation on PBAT secured nearly $100,000 (RS1 crore) in seed funding, allowing him to launch the project. “I tried to balance both my studies and the operations of the company—from collecting raw material, assisting workers to manufacture bags, delivering the products in the market,” Mohiuddin told The Better India. “I used to sleep in a corner in the factory.”

Despite facing bankruptcy, university challenges, and a backlog of orders, Bio Reform eventually turned a profit and now produces nearly 500,000 bags annually, with a gross revenue of $180,000.

“Issues related to plastic pollution are not limited to affecting aquatic life and animals anymore. Today, microplastic has reached our bloodstream. Bottled water contains microplastics. Addressing this is an important and urgent problem,” he told TBI.

Amazing Roman Engineering Still Used Today

Thanks to the advanced craftsmanship of ancient Roman architects and their remarkably durable building materials, many of the empire’s most impressive structures still stand today, attracting millions of tourists—over 6 million visit the Colosseum alone each year. However, perhaps the most astonishing engineering feat of ancient Rome is its iconic aqueducts, one of which continues to supply water to the city millennia after it was built.

While the Romans didn’t invent the aqueduct Roman engineers perfected the concept. The Acqua Vergine, originally built as the Aqua Virgo during Emperor Augustus’s reign in 19 BC, still delivers water to Rome more than 2,000 years after its creation. Though it has undergoing several restorations over the centuries.

The extraordinary longevity of Rome’s aqueducts and other ancient structures can be attributed to the city’s near-miraculous concrete recipe. Researchers at the Massachusetts Institute of Technology (MIT) have found that Roman concrete possesses a unique ability to self-heal, thanks to the presence of lime clasts (small mineral chunks) and a technique known as “hot mixing,” where lime is mixed at extremely high temperatures. Today, scientists are exploring the secrets of this ancient material with the hope of applying Rome’s ancient wisdom to modern construction practices.

Another interesting fact of Rome’s historical water engineering prowess is that the city boasts more water fountains than any other city in the world. Although estimates suggest there may be as many as 3,000 fountains, many of them are no longer in operation.

If you want to know how Roman aqueducts work, and how incredible long they can be, check out this video. It is very good! It also explains how the aqueducts were not used for what you might think they were used for.

FDA Approves Drug That Targets Brain Cancer Gene Mutation

This month, the U.S. Food and Drug Administration approved a new drug for IDH-mutant low-grade glioma, a type of brain cancer. The drug, vorasidenib, is a targeted therapy that inhibits the IDH gene mutation, slowing cancer growth.

The IDH gene was first identified in 2008 by Dr. Bert Vogelstein and his team at Johns Hopkins, who mapped the genetic blueprint of brain cancer. This discovery revealed that IDH mutations are common in certain brain tumors, which had not been previously recognized.

Typically, treatment involves surgery, followed by radiation and chemotherapy. Vorasidenib may allow some patients to delay these additional treatments. According to Matthias Holdhoff, M.D., Ph.D., co-director of the Johns Hopkins Kimmel Cancer Center brain tumor program, this drug could become a new standard for treating slow-growing IDH-mutant gliomas.

A phase 3 clinical trial published in the New England Journal of Medicine showed that vorasidenib significantly improved progression-free survival for 331 patients with grade 2 IDH-mutant glioma, compared to a placebo. Vogelstein’s research also led to a new classification for gliomas, distinguishing between those with IDH mutations, which generally have better outcomes, and those without, such as glioblastoma, a more aggressive form of brain cancer.

About 80% of low-grade gliomas have IDH mutations. These tumors, which mostly affect younger adults, grow more slowly and are linked to longer survival rates compared to high-grade gliomas. Vogelstein notes that understanding diseases through research ultimately leads to better treatments.

The IDH discovery has also spurred further research into other brain cancers. Johns Hopkins University holds patents for the IDH discovery, licensed to Servier Laboratories, which funded the phase 3 trial. The university and its inventors, including Vogelstein, will receive royalties from this licensing agreement.

Removing Microplastics Now

Earlier this week we featured an article about two highschool students that developed a novel water filtration device that uses sound waves to remove microplastics from water. They are now working on a way to implement this technology across a wide range of industries and use cases that are badly in need of such a device.

However, researchers just recently discovered another method of removing microplastics contamination from drinking water that is right at your fingertips.

A group of scientists discovered that simply boiling water can remove between 25% and 90% of the microplastics present.

In a study conducted by Guangzhou University, researchers tested two types of tap water—hard water and soft water. Hard tap water is richer in minerals, especially calcium carbonate (limescale), compared to soft water. Anyone who uses an electric kettle or coffee maker is familiar with the limescale buildup that requires periodic cleaning. When the scientists boiled the hard tap water, the calcium carbonate precipitated out of the solution, effectively trapping a variety of plastic particles ranging in size from 5 to 10 micrometers. Remarkably, 90% of these particles were captured in the limescale layer.

The researchers noted, This simple boiling water strategy can ‘decontaminate’ [nano and microplastics] from household tap water and has the potential for harmlessly alleviating human intake of NMPs through water consumption,” in their paper published in February. Even in soft water, which contains less calcium carbonate, roughly 25% of the microplastics were removed. It’s worth noting that most bottled water sold in the U.S. is hard water, as is much of the tap water across the country. Some brands use reverse osmosis or other methods to dissolve minerals, then sell the water as either soft water or ‘mineral water’ after re-adding minerals.

It is estimated that there may be as much as 7 credit cards’ worth of plastic circulating in your body at any given time. While the long-term effects of this contamination are still unknown, studies in mice have found microplastics in every organ, including the brain and placenta.

If you don’t want to wait for the slower, more comprehensive solutions, like the sonic filter, filtering and boiling your drinking water could be a great option. Or just drink tea I guess.

94-Year-Old Becomes Oldest to Tackle World’s Fastest Zip Line

A 94-year-old Englishman, David Aris, took on the world’s fastest zip line to raise money for his local hospice care. David, a great-grandfather, lost his wife, June, to cancer five years ago. St John’s Hospice, which cared for June in her final months, also provided end-of-life care for a friend of David’s, Mr. Kilby.

David and Narelle, Mr. Kilby’s 70-year-old widow, visited Zip World in Penrhyn Quarry, Wales, where they rode the zip line, reaching speeds of up to 100 mph (160 km/h), to raise funds for the hospice.

“I’d heard of the zip line, but I didn’t consider it until Narelle suggested it,” David told the media. “When I called to book and mentioned I was 94, they said I was likely the oldest person to try it, and it turned out to be true!”

David described the experience as nerve-wracking but exhilarating, noting that the ride was over in less than a minute due to its speed.

David and Narelle have raised over £9,500 through JustGiving to support the hospice that helped them during a difficult time.