Scientists Decode Key Cancer Mutation

A new study from the University of Chicago, published in Nature, reveals an important role of RNA in how DNA is stored and organized in cells through a gene called TET2. This finding explains why TET2 mutations are linked to various cancers and diseases. Led by Prof. Chuan He, the research team found that TET2 affects RNA rather than DNA, specifically influencing RNA packaging via methylation. This process attracts the MBD6 protein, essential for organizing chromatin (DNA packaging).

In cancers, TET2 mutations lead to chromatin dysregulation, promoting uncontrolled cell growth, especially in blood and brain cells. Targeting this pathway could provide new cancer therapies, and the team is developing drugs focused on this mechanism. Beyond cancer, TET2 mutations in older adults are associated with inflammatory conditions like heart disease and diabetes, offering potential treatment avenues to remove mutant cells before they cause harm. This study also expands our understanding of chromatin regulation, suggesting RNA modifications play a broad role in gene expression.

The Mystery of the Nazca Culture

After nearly a century of searching, archaeologists used AI to survey the Nazca Desert in Peru, uncovering an additional 303 geoglyphs in a single study period.

Nazca’s geoglyphs remain one of anthropology’s great puzzles. Why did the Nazca culture, active around the first century BCE, carve these vast patterns of animals and human figures into the desert floor? The research team—scientists and archaeologists from Japan, France, Germany, and New York—trained their AI model with only 430 known geoglyphs, unlike medical AI that studies thousands of images. When tasked with scanning aerial photographs of the desert, the AI flagged 47,000 potential matches. The team narrowed this down to 1,309 high-potential candidates and then identified 303 new geoglyphs through field verification and drone support.

Of these 303, 178 were suggested by the AI, while 125 were discovered in the field. Notably, 66 were part of an AI-identified cluster, while 59 were found independently of AI. The purpose of the Nazca lines remains unclear. Theories suggest they could be a calendar, a ceremonial site, or have played a role in communication or ritual. The symbols, classified as either line-type or relief-type, vary significantly. Line-type geoglyphs are large, geometric, and visible only from the air, averaging about 90 meters (300 feet). Relief-types, depicting humans, heads, or animals, are much smaller, often visible from the ground.

Dog Saves Owner’s Life

In Washington state, an 84-year-old man was saved by his dog, Gita, after he fell and couldn’t move due to a leg injury.

On September 25th, the unnamed man fell outside his home. Gita ran to a main road, where she stood in traffic to get help. Deputy Wright, who was patrolling the area in Stevens County, noticed the dog but didn’t see any houses or her owner. He tried to coax Gita into his patrol car, but she refused to move. After checking nearby residences with no luck, Deputy Wright returned to Gita, who had laid down in the center of the road.
When he attempted to move her again, she took off down a steep, unmarked side road. Wright followed her, which led him to a small cabin. There, he found the elderly man on the ground, calling for help. He had been lying there for hours and had other medical conditions requiring regular medication. If Gita hadn’t led Wright to him, the situation would have ended badly.

Strange Rock Found on Mars

While exploring Mars the Perseverance rover spotted a striking rock with black and white striations, similar to Alpine granite. NASA scientists are intrigued, as this could signal a region with new insights about the planet.

The rock, named Freya Castle, stands out in Jezero Crater, a site mostly composed of bedrock and sedimentary layers. NASA’s Jet Propulsion Laboratory used the rover’s Mastcam-Z to take a closer look, suspecting it to be a metamorphic rock. If confirmed, it could offer valuable details about Mars’ volcanic history, suggesting the rock may have fallen into the crater from higher elevations. Scientists, including Klidaras, are now watching for more deposits of this type, which could help determine if the rocks were uplifted by the Jezero impact or transported by ancient volcanic activity.

NASA’s Perseverance Mars rover took this selfie over a rock on September 10, 2021 Credits: NASA/JPL-Caltech/MSSS

Scientists Grow 1,000-Year-Old Seed

Forty years ago, an archaeological dig north of Jerusalem uncovered a well-preserved ancient seed, estimated to be over 1,000 years old. Recently planted, it has now grown into a mature tree, possibly a long-extinct species once used for medicinal purposes, and even mentioned in the Bible.

Initially, Israeli botanists, including Dr. Sarah Sallon of the Hadassah University Medical Center, couldn’t identify the seed’s species. Following a technique used to germinate ancient date palm pits, Dr. Sallon treated the seed with hormones, liquid fertilizer, and water, then planted it. Five weeks later, despite a millennium of environmental exposure, it sprouted. Now standing 10 feet tall, the tree has garnered global interest. Based on genetic analysis and expert consultation, Dr. Sallon’s team believes the tree might belong to the Commiphora genus, related to the myrrh tree. However, chemical tests showed no traces of the fragrant compounds found in Judean Balsam, a historic medicinal plant they initially suspected. Instead, the leaves contain guggulterols, a group of phytochemicals also found in Commiphora wightii, known for its potential cancer-fighting properties.

The tree, now 14 years old- credit, Guy Eisner, supplied to the media

Ancient texts, including the Bible, refer to a medicinal balm called ‘tsori.’ Dr. Sallon’s team believes this is what they may have rediscovered, although confirmation will only come once the tree produces flowers or fruit. Dr. Louise Colville from the Royal Botanic Gardens, Kew, praised the achievement of reviving a seed this old, highlighting its significance for the potential of long-term seed preservation. “Seeing the potential for such extreme longevity gives us hope for seed banking and storage,” she commented.