College Lab Makes 3D Printed Arms

12-year-old Aubrey Sauvie never let her lack of hands stop her from pursuing Tae Kwon Do, art, or doing her own makeup.

Born a triple congenital amputee and missing both arms from below the elbows and several toes on one foot, Aubrey quickly showed her family she didn’t need much accommodation. “It’s just one part of me,” Aubrey told WKRN. “It doesn’t define me. Learning was a challenge, but over time it became easier.”

Aubrey’s family album is full of pictures of her in dance competitions, breaking boards with a flying side-kick, and playing snare drum in her school band with drumsticks in her elbow creases. But playing the snare didn’t produce the sound she wanted. Her middle school band teacher suggested she join the Tennessee Tech University program, Engineering for Kids, where 10 students made it their project to create custom prosthetics for her to play the drums.

The students designed a 3D-printed pair of durable, flexible prosthetics with interchangeable grips. Tennessee Tech Professor of Mechanical Engineering Stephen Canfield called it a one-in-a-million shot. The students spent the semester taking measurements and testing prototypes. Their hard work paid off, surprising them and delighting Aubrey.

Now, Aubrey enjoys the proper snap of a snare hit and dreams of playing a full drum kit.

Light Therapy for Brain Injuries

Research has long examined how different wavelengths of light aid wound healing. A recent study in the journal Radiology indicates that low-level light therapy (LLLT) may also help heal significant brain injuries. Massachusetts General Hospital researchers conducted LLLT on 38 patients with moderate traumatic brain injuries, which affect cognition or show up on brain scans. Using a helmet that emits near-infrared light, they administered the therapy within 72 hours of injury.

“Near-infrared light penetrates the skull well,” said Dr. Rajiv Gupta, co-lead author from the Department of Radiology at Mass General. “The helmet bathes the entire brain in light.” The researchers used functional MRI to measure the therapy’s impact, focusing on the brain’s resting-state functional connectivity—communication between brain regions when at rest.

They compared MRI results across three recovery phases: acute (within one week), subacute (two to three weeks), and late-subacute (three months). Of the 38 patients, 21 did not receive light therapy to serve as controls. Patients who received LLLT showed greater changes in resting-state connectivity in seven brain region pairs during the acute-to-subacute phase compared to the control group.

“Increased connectivity was seen mainly in the first two weeks,” said study coauthor Nathaniel Mercaldo, Ph.D. The next step is to study long-term effects. The exact mechanism of LLLT’s effect on the brain remains unknown, but previous research suggests it alters an enzyme in the cell’s mitochondria, leading to more production of adenosine triphosphate (ATP), a key energy molecule. LLLT is also associated with blood vessel dilation and anti-inflammatory effects.

The 810-nanometer-wavelength light used in the study is safe, easy to administer, and does not require surgery or medications. The helmet’s portability allows for use outside hospital settings. According to Dr. Gupta, LLLT may help treat other neurological conditions, such as PTSD, depression, and autism. As more research emerges, the role of light therapy is likely to expand.

(SOURCE: Radiology, published by the Radiological Society of North America)

Sunbeam-Powered Portable Factory

A startup has developed a portable factory that uses solar energy to produce high-quality plastic products such as water tanks and boat frames. This factory, which can be transported globally via shipping containers, offers speed and flexibility, making it ideal for various applications from disaster relief to rural development.

The technology, called Solar Rotational Molding (SRM), involves placing raw plastic in a mold and heating it with concentrated sunlight using 30 heliostats. These mirrors adjust automatically to follow the sun, ensuring continuous exposure.

Karl von Kries, the founder of Light Manufacturing and inventor of SRM, started his entrepreneurial journey after noticing high energy costs at a Massachusetts-based company where he previously worked. Inspired by the potential of solar heat, he established Light Manufacturing to explore solar rotational molding, despite initial skepticism about its feasibility.

To his surprise, the solar molding process proved successful. By 2014, the company was producing high-quality plastic parts and had secured several patents. Von Kries sees SRM as a valuable tool for providing essential infrastructure in rural areas of developing countries, such as pipes and rainwater tanks.

The SRM system, housed in a shipping container, includes a rotational axis, control panels, and electrical components, requiring only an acre of flat land for setup. This setup is significantly cheaper than traditional molding systems, costing one-tenth as much. With minimal operating costs and a two-person crew, the system produces finished products at 20-30% lower costs than conventional methods.

Light Manufacturing has already deployed a system in Hawaii, demonstrating the practical application of their technology.

Edible Carbon Beads Reduce Liver Cirrhosis

Researchers at University College London have developed innovative carbon beads that reduce harmful bacteria and inflammation in animal models, addressing issues linked to liver cirrhosis and other serious health problems.

Published in the journal Gut, the study found these carbon beads effectively restored gut health and improved liver, kidney, and brain function in rats and mice. The beads were also deemed safe for human use.

Professor Rajiv Jalan from the UCL Institute for Liver and Digestive Health explained that an imbalance in the microbiome allows harmful bacteria to outcompete beneficial bacteria, leading to gut inflammation and organ damage.

In liver cirrhosis, characterized by liver scarring affecting 100 million people globally, inflammation from endotoxins worsens liver damage. Standard treatments like antibiotics pose risks of resistance and are used only in advanced stages.

To address this, UCL scientists developed oral carbon beads, designed to adsorb harmful molecules in the gut. Known as CARBALIVE, these beads were tested on liver, kidney, and brain function in rats and mice. Daily ingestion for several weeks prevented liver scarring progression and reduced mortality in acute liver failure.

Licensed to UCL-spinout Yaqrit, the beads were tested on 28 cirrhosis patients, proving safe with minimal side effects. If human trials replicate animal model results, the beads could significantly combat liver disease.

“These carbon beads, smaller than a grain of salt, absorb endotoxins and harmful metabolites in the gut, preventing damage to other organs,” said Michal Kowalski, CARBALIVE product lead at Yaqrit. “Animal model results show reduced gut permeability and improved liver, brain, and kidney function.”

Further human trials are planned to confirm efficacy. If successful, these beads could be a valuable treatment for liver disease and other conditions related to poor microbiome health, such as irritable bowel syndrome.

With funding from a European Union innovation program, a factory was built to manufacture the beads and continue research into their potential uses.

“I am hopeful that these beads will soon be approved to treat liver disease and other conditions,” added Jalan, a Hepatology professor at UCL.

FAA Certifies First Air Taxi

The Federal Aviation Administration (FAA) has granted Archer Aviation a crucial certification, moving the electric air taxi maker closer to flying travelers.

Archer is developing electric vertical takeoff and landing aircraft, or eVTOLs, and won orders and backing from United Airlines in 2021.

Airlines have been investing in or ordering eVTOL aircraft, which take off and land vertically like helicopters. For instance, United Airlines envisions passengers using them for trips to and from airports in major cities, such as between Manhattan and United’s hub in Newark, New Jersey.

Related article: Flying Cars… Sort Of

“Today we have received the Part 135 certification, which allows us to effectively become an airline so we can carry passengers,” Archer CEO Adam Goldstein told CNBC.

The certification process took Archer about two years, during which they submitted over 2,000 pages of documents and 14 manuals outlining operational procedures, training, and maintenance.

Archer now needs to get its four-passenger aircraft, called “Midnight,” certified by the FAA. Goldstein mentioned that the company is currently working on this, with the possibility of air taxis entering service as early as next year. While he couldn’t provide an exact timeframe, he noted that Archer’s aircraft are much simpler with far fewer components than commercial jets, which might expedite the certification process.

Related: The Future of Flying

Archer’s demonstrator aircraft, Maker, can fly up to 60 miles at top speeds of 150 mph. The company’s Midnight aircraft, the bigger of the two, has a range of 100 miles, although Archer plans to use it primarily for shorter distances.

Here are two videos showing off their two models: